Human DRD2 Protein, Flag, His Tag (Detergent)
Dopamine receptor D2 (DRD2) is G protein-coupled receptor (GPCR) that belong to the D2-like dopamine receptor family, couple to Gi to reduce adenylyl cyclase. DRD2s are expressed in different neuronal cell types within the striatum, dopamine binding leads to the inhibition of dopaminergic synaptic transmission. Altered expression level and function of DRD2s are observed in Parkinson's disease, making DRD2 one of the most common therapeutic targets for Parkinson's disease. DRD2 agonists can reduce the side effects of L-DOPA and enhance the therapeutic effect.
Product Specifications
Background
Specifications
This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 48.3 kDa.
Accession Number
P14416-1
Expression Region
Asn 35 - Arg 222 & Lys 362 - Cys 443
Host
HEK293
Target
DRD2
Conjugation
Unconjugated
Tag
N-Flag & C-10xHis
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Additives
Glycerol
Molecular Weight
48.3 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
500ug*1
Host or Source
HEK293
Species
Human
Protein ID
P14416-1
Preservative
Glycerol
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