GCN2-IN-7

GCN2-IN-7 (compound 39) is an orally active and selective general control nonderepressible 2 (GCN2) inhibitor (IC50=5 nM) . GCN2-IN-7 shows anti-tumor activity in vivo[1].

Product Specifications

CAS Number

[2396465-33-9]

UNSPSC

12352005

Target

Eukaryotic Initiation Factor (eIF)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gcn2-in-7.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@]1(C)C[C@H](NC2=NC=C3C(N(C4=CC=C(C5=NN=C(C)S5)C=C4)N=C3Br)=N2)CC1)NC

Molecular Formula

C22H23BrN8OS

Molecular Weight

527.44

References & Citations

[1]Jackson JJ, et al. Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy. J Med Chem. 2022 Sep 20.