Guanidine-13C,15N3 (hydrochloride)

Guanidine-13C,15N3 (hydrochloride) is the 13C-labeled and 15N-labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2].

Product Specifications

CAS Number

[285977-73-3]

Product Name Alternative

Guanidinium-13C,15N3 (chloride) ; Aminoformamidine-13C,15N3 (hydrochloride)

UNSPSC

12352211

Hazard Statement

H302-H318

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/guanidine-13c-15n3-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.[15NH]=[13C]([15NH2])[15NH2]

Molecular Formula

13CH6Cl 15N3

Molecular Weight

99.50

Precautions

P264-P270-P280-P305+P351+P338-P330-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231 (2) :180-4.|[3]G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul;43 (1) :7-10.|[4]Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8;450 (4) :1339-44.|[5]E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec;2 (6) :339-46.