HPK1-IN-2 (dihydrochloride)
HPK1-IN-2 dihydrochloride is a potent and orally active hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50IC50IC50[1].
Product Specifications
CAS Number
[2375595-72-3]
UNSPSC
12352005
Target
FLT3; MAP4K; Src
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-2-dihydrochloride.html
Concentration
10mM
Purity
97.09
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=C1C(C2=NC3=CC=C(N4CCN(C)CC4)C=C3N2)=C(N)C(C=CS5)=C5N1.[H]Cl.[H]Cl
Molecular Formula
C19H22Cl2N6OS
Molecular Weight
453.39
References & Citations
[1]Peter Brent Sampson, et al. Hpk1 inhibitors and methods of using same. WO2016205942A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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