What is the catalog number for ISO-1?

The catalog number for ISO-1 is HY-16692.

What sizes are available for ISO-1?

ISO-1 is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 100 mg, 500 mg, 1 g.

How many pack sizes does ISO-1 come in?

ISO-1 is available in 7 different pack sizes.

ISO-1 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ISO-1?

ISO-1 is manufactured by QuantiMol.

What is the estimated delivery time for ISO-1?

Estimated delivery time for ISO-1 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for ISO-1?

The safety data sheet for ISO-1 is available here: http://file.medchemexpress.com/batch_PDF/HY-16692/ISO-1-SDS-MedChemExpress.pdf.

ISO-1

ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.

Product Specifications

CAS Number

478336-92-4

Product Name Alternative

MIF Antagonist

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Macrophage migration inhibitory factor (MIF)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ISO-1.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

Smiles

O=C(OC)CC1ON=C(C(C=C2)=CC=C2O)C1

Molecular Formula

C12H13NO4

Molecular Weight

235.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277 (28) :24976-82.|[2]Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280 (44) :36541-4.|[3]Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3 (3) :135-142.