MP-Ala-Ala-PAB
Product Specifications
UNSPSC Description
MP-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
Target Antigen
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mp-ala-ala-pab.html
Solubility
DMSO : 350 mg/mL (ultrasonic)
Smiles
OCC(C=C1)=CC=C1NC([C@H](C)NC([C@H](C)NC(CCN2C(C=CC2=O)=O)=O)=O)=O
Molecular Weight
416.43
References & Citations
[1]Wayne C Widdison, et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing. Bioconjug Chem. 2015 Nov 18;26(11):2261-78.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148463/MP-Ala-Ala-PAB-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148463/MP-Ala-Ala-PAB-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1949793-47-8
Available Sizes
Curated Selection
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