DL-AP4

DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system[1][2][3].

Product Specifications

CAS Number

[6323-99-5]

Product Name Alternative

2-Amino-4-phosphonobutyric acid

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dl-ap4.html

Purity

98.0

Solubility

H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C(N)CCP(O)(O)=O

Molecular Formula

C4H10NO5P

Molecular Weight

183.10

Precautions

H302, H312, H332

References & Citations

[1]Cull-Candy SG, et al. 2-Amino-4-phosphonobutyric acid as a glutamate antagonist on locust muscle. Nature. 1976 Jul 29;262 (5567) :408-9.|[2]Crooks SL, et al. Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding. J Med Chem. 1986 Oct;29 (10) :1988-95.|[3]Yamashita M, et al. Responses of rod bipolar cells isolated from the rat retina to the glutamate agonist 2-amino-4-phosphonobutyric acid (APB) . J Neurosci. 1991 Aug;11 (8) :2372-82.|[4]Ellis EM, et al. Separate ON and OFF pathways in vertebrate vision first arose during the Cambrian. Curr Biol. 2020 Jun 8;30 (11) :R633-R634.