Encenicline hydrochloride
Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) .
Product Specifications
CAS Number
550999-74-1
Product Name Alternative
EVP-6124 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/EVP-6124-hydrochloride.html
Purity
98.01
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=CC2=C(C(Cl)=CC=C2)S1)N[C@H]3CN4CCC3CC4.[H]Cl
Molecular Formula
C16H18Cl2N2OS
Molecular Weight
357.30
Precautions
H302
References & Citations
[1]Prickaerts J, et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2012 Feb;62 (2) :109|[2]Thomas Papouin, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94:1-15.|[3]Papouin T, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94 (4) :840-854.e7.|[4]Maehara S, et al. Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 2A inhibitor, PDM-631. Eur J Pharmacol. 2017 Sep 15;811:110-116.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Citation 01
Eur J Pharmacol. 2017 Sep 15:811:110-116.|Faculty of Health Sciences. 2020 Oct.|Neuron. 2017 May 17;94 (4) :840-854.e7. |Journal of High School Science. 2023 Oct 5.|Psychopharmacology. 2019 Apr;236 (4) :1245-1253.
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