Encenicline hydrochloride

Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) .

Product Specifications

CAS Number

[550999-74-1]

Product Name Alternative

EVP-6124 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/EVP-6124-hydrochloride.html

Purity

98.01

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(C1=CC2=C(C(Cl)=CC=C2)S1)N[C@H]3CN4CCC3CC4.[H]Cl

Molecular Formula

C16H18Cl2N2OS

Molecular Weight

357.30

Precautions

H302

References & Citations

[1]Prickaerts J, et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2012 Feb;62 (2) :109|[2]Thomas Papouin, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94:1-15.|[3]Papouin T, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94 (4) :840-854.e7.|[4]Maehara S, et al. Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 2A inhibitor, PDM-631. Eur J Pharmacol. 2017 Sep 15;811:110-116.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Citation 01

Eur J Pharmacol. 2017 Sep 15:811:110-116.|Faculty of Health Sciences. 2020 Oct.|Neuron. 2017 May 17;94 (4) :840-854.e7. |Journal of High School Science. 2023 Oct 5.|Psychopharmacology. 2019 Apr;236 (4) :1245-1253.