Pirenperone

Pirenperone (R 47465) is a 5-HT2 serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity[1][2].

Product Specifications

CAS Number

[75444-65-4]

Product Name Alternative

R 47465

UNSPSC

12352005

Hazard Statement

H301-H311-H331

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pirenperone.html

Purity

98.74

Solubility

0.1 M HCl : 16.67 mg/mL (ultrasonic; warming; adjust pH to 3 with 0.1 M HCl; heat to 60°C) |DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C(CCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2)=C(C)N=C4N1C=CC=C4

Molecular Formula

C23H24FN3O2

Molecular Weight

393.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

References & Citations

[1]Krstić MK, et, al. Divergent effects of pirenperone, a 5-HT2 antagonist, on the pressor and tachycardic responses to 5-HT in guinea-pigs. Arch Int Physiol Biochim. 1983 Nov;91 (4) :345-9. |[2]Ansseau M, et, al. Pilot study of a specific serotonergic antagonist, pirenperone, in the treatment of anxiety disorders. Acta Psychiatr Belg. Sep-Oct 1983;83 (5) :517-24.