Pirenperone
Pirenperone (R 47465) is a 5-HT2 serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity[1][2].
Product Specifications
CAS Number
75444-65-4
Product Name Alternative
R 47465
UNSPSC
12352005
Hazard Statement
H301-H311-H331
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pirenperone.html
Purity
98.74
Solubility
0.1 M HCl : 16.67 mg/mL (ultrasonic; warming; adjust pH to 3 with 0.1 M HCl; heat to 60°C) |DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(CCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2)=C(C)N=C4N1C=CC=C4
Molecular Formula
C23H24FN3O2
Molecular Weight
393.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
References & Citations
[1]Krstić MK, et, al. Divergent effects of pirenperone, a 5-HT2 antagonist, on the pressor and tachycardic responses to 5-HT in guinea-pigs. Arch Int Physiol Biochim. 1983 Nov;91 (4) :345-9. |[2]Ansseau M, et, al. Pilot study of a specific serotonergic antagonist, pirenperone, in the treatment of anxiety disorders. Acta Psychiatr Belg. Sep-Oct 1983;83 (5) :517-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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