TRV-120027 TFA
TRV-120027 TFA is a β-arrestin-biased AT1R agonist that selectively inhibits angiotensin II-mediated G-protein signaling while promoting β-arrestin-1 recruitment. This action inhibits vasoconstriction, enhances cardiomyocyte contractility, and triggers catecholamine secretion via a macromolecular AT1R–β-arrestin-1–TRPC3–PLCγ complex. It is a valuable research tool for studying biased GPCR signaling in cardiovascular physiology and disease models.
Product Specifications
Product Name Alternative
Field of Research
Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery
Purity
97.45% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (3.17 mM) ; DMSO:88 mg/mL (84.61 mM)
Molecular Weight
1040.1
Storage Conditions
Keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
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