MOG (35-55), human

MOG (35-55), human is a component of CNS myelin. MOG (35-55), human is different from mMOG (35-55) by a proline for serine substitution at position 42. MOG (35-55), human is also immunogenic via bind to H-2b class II MHC and recognized by T cells, but not encephalitogenic, and is only partially cross-reactive with mMOG35–55. MOG (35-55), human induces minimal clinical signs of EAE relative to the rodent peptide[1][2].

Product Specifications

CAS Number

[163158-19-8]

UNSPSC

12352209

Target

MHC

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mog-35-55-human.html

Purity

98.93

Solubility

H2O : ≥ 50 mg/mL

Smiles

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(NCC(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)NC([C@@H](NC(CNC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](N)CCSC)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O

Molecular Formula

C120H179N35O28S

Molecular Weight

2591.99

References & Citations

[1]Cathleen Rich, et al. Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. Eur J Immunol. 2004 May;34 (5) :1251-61.|[2]Alfred R Oliver, et al.Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice. J Immunol. 2003 Jul 1;171 (1) :462-8.