Flumazenil

Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.

Product Specifications

CAS Number

[78755-81-4]

Product Name Alternative

Ro 15-1788

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Flumazenil.html

Purity

99.99

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2CN(C(C3=CC(F)=CC=C3N2C=N1)=O)C)OCC

Molecular Formula

C15H14FN3O3

Molecular Weight

303.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Hoffman EJ, et al. Flumazenil: a benzodiazepine antagonist. Clin Pharm. 1993 Sep;12 (9) :641-56; quiz 699-701|[2]Belzung C, et al. Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice. Psychopharmacology (Berl) . 2000 Jan;148 (1) :24-32.|[3]Fernandez-Guasti A, et al. Flumazenil blocks the anxiolytic action of allopregnanolone. Eur J Pharmacol. 1995 Jul 25;281 (1) :113-5.|[4]Loscher W, et al. Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil. Br J Pharmacol. 1994 Dec;113 (4) :1349-57.|[5]Moy SS, et al. Flumazenil blockade of anxiety following ethanol withdrawal in rats. Psychopharmacology (Berl) . 1997 Jun;131 (4) :354-60.