ICI 216140
ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin -stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195) -stimulated increases in blood pressure[1][2].
Product Specifications
CAS Number
124001-41-8
UNSPSC
12352209
Target
Bombesin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ici-216140.html
Purity
99.78
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@H](C)C(N[C@H](C(N[C@@H](CC(C)C)C(NC)=O)=O)CC1=CN=CN1)=O)=O)=O)[C@@H](NC([C@@H](NC(C(C)C)=O)CC2=CN=CN2)=O)CC3=CNC4=CC=CC=C34
Molecular Formula
C45H65N13O8
Molecular Weight
916.08
References & Citations
[1]Camble R, et al. N-isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216140) a potent in vivo antaconist analogue of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 1989;45 (17) :1521-1527. |[2]Zogovic B, et al. Intrathecal bombesin is sympathoexcitatory and pressor in rat. Am J Physiol Regul Integr Comp Physiol. 2011;301 (5) :R1486-R1494.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNCB3092-500 1x 500 µL
HER-2 / c-erbB-2 / neu / CD340 (ERBB2/3092), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
TP307755 20 µg
Calcipressin 3 (RCAN3) (NM_013441) Human Recombinant Protein
Sign In for Pricing
View Details