ICI 216140
ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin -stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195) -stimulated increases in blood pressure[1][2].
Product Specifications
CAS Number
124001-41-8
UNSPSC
12352209
Target
Bombesin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ici-216140.html
Purity
99.78
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@H](C)C(N[C@H](C(N[C@@H](CC(C)C)C(NC)=O)=O)CC1=CN=CN1)=O)=O)=O)[C@@H](NC([C@@H](NC(C(C)C)=O)CC2=CN=CN2)=O)CC3=CNC4=CC=CC=C34
Molecular Formula
C45H65N13O8
Molecular Weight
916.08
References & Citations
[1]Camble R, et al. N-isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216140) a potent in vivo antaconist analogue of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 1989;45 (17) :1521-1527. |[2]Zogovic B, et al. Intrathecal bombesin is sympathoexcitatory and pressor in rat. Am J Physiol Regul Integr Comp Physiol. 2011;301 (5) :R1486-R1494.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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