ICI 216140

ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195) -stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195) -stimulated increases in blood pressure[1][2].

Product Specifications

CAS Number

[124001-41-8]

UNSPSC

12352209

Target

Bombesin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ici-216140.html

Purity

99.78

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@H](C)C(N[C@H](C(N[C@@H](CC(C)C)C(NC)=O)=O)CC1=CN=CN1)=O)=O)=O)[C@@H](NC([C@@H](NC(C(C)C)=O)CC2=CN=CN2)=O)CC3=CNC4=CC=CC=C34

Molecular Formula

C45H65N13O8

Molecular Weight

916.08

References & Citations

[1]Camble R, et al. N-isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216140) a potent in vivo antaconist analogue of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 1989;45 (17) :1521-1527. |[2]Zogovic B, et al. Intrathecal bombesin is sympathoexcitatory and pressor in rat. Am J Physiol Regul Integr Comp Physiol. 2011;301 (5) :R1486-R1494.