TH9619

TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells. TH9619 induces apoptosis by blocking the S phase. TH9619 has antitumor activity[1][2].

Product Specifications

CAS Number

[2379556-22-4]

UNSPSC

12352005

Target

Apoptosis; Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/th9619.html

Purity

99.33

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC(NC(N)=NC1=O)=C1CC(NC2=CN=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C(F)=C2)=O

Molecular Formula

C17H18FN7O7

Molecular Weight

451.37

References & Citations

[1]Bonagas N, et al. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer. 2022 Feb;3 (2) :156-172.|[2]Green AC, et al. Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nat Metab. 2023 Apr;5 (4) :642-659.