Gabapentin enacarbil

Gabapentin enacarbil (XP-13512) is a prodrug of Gabapentin (HY-A0057) designed to be absorbed throughout the intestine by high-capacity nutrient transporters. Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin enacarbil can be used for the study of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN) [1][2].

Product Specifications

CAS Number

[478296-72-9]

Product Name Alternative

XP-13512

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Gabapentin-enacarbil.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL|Ethanol : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CC1(CNC(OC(OC(C(C)C)=O)C)=O)CCCCC1

Molecular Formula

C16H27NO6

Molecular Weight

329.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Cundy KC, et al. XP13512 [ (+/-) -1- ([ (alpha-isobutanoyloxyethoxy) carbonyl] aminomethyl) -1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters. J Pharmacol Exp Ther. 2004 Oct;311 (1) :315-23.|[2]Cundy KC, et al. XP13512 [ (+/-) -1- ([ (alpha-isobutanoyloxyethoxy) carbonyl] aminomethyl) -1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys. J Pharmacol Exp Ther. 2004 Oct;311 (1) :324-33.