Bepotastine (besilate)

Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF) . Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research[1][2][3][4].

Product Specifications

CAS Number

[190786-44-8]

UNSPSC

12352005

Hazard Statement

H361

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Bepotastine-Beslilate.html

Purity

99.77

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(CCCN1CCC(CC1)O[C@H](C2=NC=CC=C2)C3=CC=C(C=C3)Cl)O.O=S(C4=CC=CC=C4)(O)=O

Molecular Formula

C27H31ClN2O6S

Molecular Weight

547.06

Precautions

H361

References & Citations

[1]Kida T, et al. Bepotastine besilate, a highly selective histamine H (1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res. 2010 Jul;91 (1) :85-91.|[2]Kamata Y, et al. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 2018 Apr 23:S0923-1811 (18) 30186-5.|[3]Tanizaki H, et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol. 2008;145 (4) :277-82.|[4]Jon I Williams, et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin. 2010 Oct;26 (10) :2329-38.