Thalidomide-O-amido-C4-NH2 (TFA)

Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

Product Specifications

CAS Number

[1799711-25-3]

Product Name Alternative

Cereblon Ligand-Linker Conjugates 6 (TFA) ; E3 ligase Ligand-Linker Conjugates 19 (TFA)

UNSPSC

12352005

Hazard Statement

H301, H312, H361

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_16.html

Purity

99.92

Solubility

DMSO : 42.86 mg/mL (ultrasonic)

Smiles

NCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O.FC(F)(F)C(O)=O

Molecular Formula

C21H23F3N4O8

Molecular Weight

516.42

Precautions

H301, H312, H361

References & Citations

[1]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2017 Mar 24.|[2]James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.