JNJ-40411813

JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. JNJ-40411813 has orally bioactivity and penetrate the blood-brain barriers. JNJ-40411813 has the potential property of anti-depression[1][2][3].

Product Specifications

CAS Number

[1127498-03-6]

Product Name Alternative

ADX-71149

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jnj-40411813.html

Purity

99.85

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C(Cl)=C(N2CCC(C3=CC=CC=C3)CC2)C=CN1CCCC

Molecular Formula

C20H25ClN2O

Molecular Weight

344.88

Precautions

H315, H319, H320

References & Citations

[1]Cid JM, et al. Discovery of 1-Butyl-3-chloro-4- (4-phenyl-1-piperidinyl) - (1H) -pyridone (JNJ-40411813) : A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor. J Med Chem. 2014 Aug 14;57 (15) :6495-512.|[2]Hilde Lavreysen, et al. Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor. Pharmacol Res Perspect 2015 Feb;3 (1) :e00096.|[3]Dunlop J, Schizophrenia, et al. Schizophrenia drug discovery and development in an evolving era: are new drug targets fulfilling expectations?. Journal of Psychopharmacology. 29 (2) : 230–8.