(E/Z) -GO289

(E/Z) -GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM) . (E/Z) -GO289 strongly lengthens circadian period. (E/Z) -GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function[1].

Product Specifications

CAS Number

[694522-87-7]

Product Name Alternative

CP 526555

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Casein Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e-z-go289.html

Concentration

10mM

Purity

98.98

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=CC(Br)=C(/C=N/N2C(SC)=NN=C2C3=CC=CC=C3)C=C1OC

Molecular Formula

C17H15BrN4O2S

Molecular Weight

419.30

Precautions

H315, H319

References & Citations

[1]Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5 (1) :eaau9060. Published 2019 Jan 23.