FeTMPyP

FeTMPyP is an orally active peroxynitrite (ONOO) scavenger. FeTMPyP reduces nitrative stress and increases autophagy. FeTMPyP reduces PARP over-activation and neuroinflammation in chronic constriction injury (CCI) -induced rats, and ameliorates functional, behavioral and biochemical deficits[1][2].

Product Specifications

CAS Number

[133314-07-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fetmpyp.html

Purity

99.80

Solubility

10 mM in DMSO

Smiles

C[N+](C=C1)=CC=C1C2=C3C=CC(C(C4=CC=[N+](C)C=C4)=C5C=CC([N-]56)=C7C8=CC=[N+](C)C=C8)=[N]3[Fe+3]96[N]%10=C7C=CC%10=C(C%11=CC=[N+](C)C=C%11)C%12=CC=C2[N-]%129.[5Cl-]

Molecular Formula

C44H36Cl5FeN8

Molecular Weight

909.92

Precautions

H315, H319, H335

References & Citations

[1]Zhang S, et al. Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. Oxid Med Cell Longev. 2020 Jan 25;2020:4252047.|[2]Komirishetty P, et al. FeTMPyP a peroxynitrite decomposition catalyst ameliorated functional and behavioral deficits in chronic constriction injury induced neuropathic pain in rats. Free Radic Res. 2021 Oct;55 (9-10) :1005-1017.