Cromolyn-d5
Cromolyn-d5 (Cromoglycate-d5) is the deuterium labeled Cromolyn (HY-B1619) . Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects[1].
Product Specifications
CAS Number
[2140317-08-2]
Product Name Alternative
Cromoglycate-d5; Cromoglicic acid-d5; FPL-670-d5 (free acid)
UNSPSC
12352005
Target
Amyloid-β; GSK-3; Isotope-Labeled Compounds; NF-κB
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility
10 mM in DMSO
Smiles
OC(C([2H])([2H])OC1=C2C(C=C(C(O)=O)OC2=CC=C1)=O)([2H])C([2H])([2H])OC3=C4C(C=C(C(O)=O)OC4=CC=C3)=O
Molecular Formula
C23H11D5O11
Molecular Weight
473.40
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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