Impurity C of Calcitriol

Impurity C of Calcitriol is the impurity of Calcitriol (HY-10002) . Calcitriol is the hormonally active form of vitamin D. Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR) .

Product Specifications

CAS Number

[86307-44-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

VD/VDR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/impurity-c-of-calcitriol.html

Purity

99.84

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@@H](C[C@@H]1O)CC([C@@H]2C=C3[C@@](CC[C@]4([H])[C@@H](CCCC(C)(O)C)C)([H])[C@]4(C)CC[C@@]3([H])N(C(N5C6=CC=CC=C6)=O)N2C5=O)=C1C

Molecular Formula

C35H49N3O5

Molecular Weight

591.78

Precautions

H302, H315, H319, H335

References & Citations

[1]Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004) |[2]Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373.|[3]Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.|[4]Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.