Brevifolincarboxylic acid

Brevifolincarboxylic acid is a phenolic compound. Brevifolincarboxylic acid can be isolated from Duchesnea chrysantha. Brevifolincarboxylic acid inhibits α-glucosidase with an IC50 value of 323.46 μM. Brevifolincarboxylic acid has an inhibitory effect on the aryl hydrocarbon receptor (AhR) . Brevifolincarbacid scavenges ROS. Brevifolincarbacid restores the glucose uptake activity of myotubes. Brevifolincarboxylic acid has antitumor activity against lung and gastric cancer. Brevifolincarbacid can be used in the study of diabetes and inflammatory diseases[1][2][3][4][5][6].

Product Specifications

CAS Number

[18490-95-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Aryl Hydrocarbon Receptor; GLUT; Glycosidase; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/brevifolincarboxylic-acid.html

Purity

99.90

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(C1CC(C2=C1C3=C(O)C(O)=C(O)C=C3C(O2)=O)=O)O

Molecular Formula

C13H8O8

Molecular Weight

292.20

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Chen X, et al. Simultaneous isolation and purification of gallic acid and brevifolincarboxylic acid from Polygonum capitatum by high-speed counter-current chromatography. Zhongguo Zhong Yao Za Zhi. 2010 Aug;35 (15) :1957-60.|[2]Amakura Y, et al. Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Pharm Bull. 2003 Dec; 26 (12) :1754-60.|[3]Liu M, et al. Separation of α-glucosidase inhibitors from Potentilla kleiniana Wight et Arn using solvent and flow-rate gradient high-speed counter-current chromatography target-guided by ultrafiltration HPLC-MS screening. Phytochem Anal. 2019 May 6.|[4]Swargiary D, et al. Free radical scavenging polyphenols isolated from Phyllanthus niruri L. ameliorates hyperglycemia via SIRT1 induction and GLUT4 translocation in in vitro and in vivo models. Fitoterapia. 2024 Mar;173:105803.|[5]Lee IR, et al. Phenolic compounds from Duchesnea chrysantha and their cytotoxic activities in human cancer cell. Arch Pharm Res. 1994 Dec;17 (6) :476-9.|[6]Lee BZ, et al. Anti-inflammatory isocoumarins from the bark of Fraxinus chinensis subsp. rhynchophylla. Nat Prod Res. 2021 Nov;35 (22) :4380-4387.