A-674563 (hydrochloride)
Product Specifications
UNSPSC Description
A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
Target Antigen
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/A-674563-hydrochloride.html
Purity
99.86
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Smiles
N[C@@H](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(C=C3)NN=C4C)=CN=C2.[H]Cl
Molecular Weight
394.90
References & Citations
[1]Luo Y, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther, 2005, 4(6), 977-986.|[2]Zhu QS, et al. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res, 2008, 68(8), 2895-2903.|[3]Zou Y, et al. Pre-clinical assessment of A-674563 as an anti-melanoma agent. Biochem Biophys Res Commun. 2016 Aug 12;477(1):1-8.|[4]Xu L, et al. Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells. Biochem Biophys Res Commun. 2016 Apr 15;472(4):662-8.Aging. 2020 Nov 17;12(22):23114-23128.|Cell Signal. 2023 Jun 9;109:110753.|J Proteome Res. 2018 Oct 5;17(10):3360-3369.|Oncotarget. 2016 May 17;7(20):29131-42.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13254A/A-674563-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13254A/A-674563-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2070009-66-2
Available Sizes
Curated Selection
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