LY5

LY5 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer[1].

Product Specifications

CAS Number

[1436382-03-4]

UNSPSC

12352005

Target

Apoptosis; STAT

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ly5.html

Purity

97.02

Solubility

DMSO : 6.25 mg/mL (ultrasonic)

Smiles

NS(=O)(C1=C2C(C(C(NC3=CC=CN=C3)=CC2=O)=O)=CC=C1)=O

Molecular Formula

C15H11N3O4S

Molecular Weight

329.33

References & Citations

[1]Yu W, et al. Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design. J Med Chem. 2013 Jun 13;56 (11) :4402-12.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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