Thiodigalactoside

Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively[1]. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[2].

Product Specifications

CAS Number

[51555-87-4]

Product Name Alternative

TDG

UNSPSC

12352005

Target

Galectin

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/thiodigalactoside.html

Concentration

10mM

Purity

99.97

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H]1O)[C@@H](O[C@@H]([C@@H]1O)CO)S[C@@H]([C@@H]([C@H]2O)O)O[C@@H]([C@@H]2O)CO

Molecular Formula

C12H22O10S

Molecular Weight

358.36

References & Citations

[1]Hilde van Hattum, et al. Tuning the Preference of Thiodigalactoside- And Lactosamine-Based Ligands to galectin-3 Over galectin-1. J Med Chem. 2013 Feb 14;56 (3) :1350-4.|[2]Varun V Prabhu, et al. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner. Cancer Res. 2015 Apr 1;75 (7) :1423-32.