SAR407899

SAR407899 is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. SAR407899 shows stable inhibition of migrasome formation.

Product Specifications

CAS Number

[923359-38-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/SAR407899.html

Purity

99.60

Solubility

DMSO : 6 mg/mL (warming)

Smiles

O=C(NC=C1)C(C1=C2)=CC=C2OC3CCNCC3

Molecular Formula

C14H16N2O2

Molecular Weight

244.29

Precautions

H302, H315, H319, H335

References & Citations

[1]L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54 (3) :676-83.|[2]Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59.|[3]Puzhong Lu, et al. Chemical screening identifies ROCK1 as a regulator of migrasome formation. Cell Discov. 2020 Aug 4;6 (1) :51.