Vapendavir (diphosphate)
Vapendavir diphosphate (BTA798 diphosphate) is a potent enteroviral capsid binder (CB) . Vapendavir diphosphate (BTA798 diphosphate) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains[1][2].
Product Specifications
CAS Number
1198151-75-5
Product Name Alternative
BTA798 (diphosphate)
UNSPSC
12352005
Target
Enterovirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vapendavir-diphosphate.html
Purity
98.72
Solubility
DMSO : 6.75 mg/mL (ultrasonic)
Smiles
CCOC1=NOC2=CC(OCCC3CCN(C4=CC=C(C)N=N4)CC3)=CC=C12.OP(O)(O)=O.OP(O)(O)=O
Molecular Formula
C21H32N4O11P2
Molecular Weight
578.45
References & Citations
[1]Tijsma A, et al. The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. Antimicrob Agents Chemother. 2014 Nov;58 (11) :6990-2.|[2]Sun L, et al. Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68. Antimicrob Agents Chemother. 2015 Dec;59 (12) :7782-5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Eur J Med Chem. 2025 Feb 14:288:117395.|Norwegian University of Science and Technology. 2023 May.|ACS Infect Dis. 2020 May 8;6 (5) :882-890.|SSRN. 2024 Apr 19.
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