S-Gboxin
S-Gboxin is a functional analog of the oxidative phosphorylation (OXPHOS) inhibitor Gboxin and has antitumor activity. S-Gboxin inhibits the growth of mouse and human glioblastoma with an IC50 of 470 nM. S-Gboxin has antitumor activity[1].
Product Specifications
CAS Number
[2101317-21-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/S-Gboxin.html
Purity
99.62
Solubility
DMSO : 93.33 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 67°C)
Smiles
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(CN2C(C=CC=C3)=C3[N+](C)=C2C4=CC(C(F)(F)F)=CC=C4)=O.[I-]
Molecular Formula
C27H32F3IN2O2
Molecular Weight
600.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Shi Y, et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019 Mar;567 (7748) :341-346.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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