DCLK1-IN-1
DCLK1-IN-1 is a selective, oral bioavailability in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1 kinase) domain. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases (IC50: DCLK1=9.5/57.2 nM and DCLK2=31/103 nM in binding and kinase assay, respectively) . DCLK1-IN-1 shows low toxicity, and can investigate DCLK1 biology and establish its role in cancer, like DCLK1+ pancreatic ductal adenocarcinoma (PDAC) [1].
Product Specifications
CAS Number
[2222635-15-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fluorescent Dye
Type
Reference compound
Related Pathways
Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dclk1-in-1.html
Purity
99.35
Solubility
DMSO : 35.71 mg/mL (ultrasonic)
Smiles
O=C1N(CC(F)(F)F)C2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3OC)N=C2N(C)C5=CC=CC=C15
Molecular Formula
C26H28F3N7O2
Molecular Weight
527.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Ferguson FM, et al. Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol. 2020 Apr 6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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