Peptide 401

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT) .

Product Specifications

CAS Number

[32908-73-9]

UNSPSC

12352209

Target

5-HT Receptor; Histamine Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Peptide_401.html

Purity

98.26

Solubility

H2O : 2.08 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H]1[C@@H](C)CC)=O)=O)=O)NC2=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)NC1=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(N[C@@H](CC5=CNC=N5)C(N[C@H]2[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CCN)N

Molecular Formula

C110H192N40O24S4

Molecular Weight

2587.22

References & Citations

[1]Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.) . Br J Pharmacol. 1974 Mar;50 (3) :383-92.|[2]Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99 (2) :350-4.