Peptide 401
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT) .
Product Specifications
CAS Number
32908-73-9
UNSPSC
12352209
Target
5-HT Receptor; Histamine Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Peptide_401.html
Purity
98.26
Solubility
H2O : 2.08 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H]1[C@@H](C)CC)=O)=O)=O)NC2=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)NC1=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(N[C@@H](CC5=CNC=N5)C(N[C@H]2[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CCN)N
Molecular Formula
C110H192N40O24S4
Molecular Weight
2587.22
References & Citations
[1]Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.) . Br J Pharmacol. 1974 Mar;50 (3) :383-92.|[2]Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99 (2) :350-4.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Histamine Receptor; MUC4
Available Sizes
Frequently Asked Questions
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