GNF-PF-3777

GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.

Product Specifications

CAS Number

[77603-42-0]

Product Name Alternative

8-Nitrotryptanthrin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/8-Nitrotryptanthrin.html

Purity

98.03

Solubility

DMSO : 6.4 mg/mL (warming)

Smiles

O=C1N2C(C(C3=C2C=CC([N+]([O-])=O)=C3)=O)=NC4=CC=CC=C41

Molecular Formula

C15H7N3O4

Molecular Weight

293.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Li J, et al. Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016 Nov 10;123:171-9.|[2]Scovill J, et al. Antitrypanosomal activities of tryptanthrins. Antimicrob Agents Chemother. 2002 Mar;46 (3) :882-3.|[3]Hwang JM, et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013 Mar 22;76 (3) :354-67.