PROTAC SMARCA2/4-degrader-3

SMARCA2/4-degrader-3 (compound I-433) is a PROTAC SMARCA2/4-degrader based on VH032-NH2, with a degradation potency (DC50) [1].

Product Specifications

CAS Number

[2568507-10-6]

UNSPSC

12352005

Target

PROTACs

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-smarca2-4-degrader-3.html

Smiles

O=C([C@H]1N(C[C@H](O)C1)C([C@@H](NC(C2CC3(CC(C4=CC=C(CN5CCC(CC5)CN6N=CC(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)=C6)C=C4)C3)C2)=O)C(C)(C)C)=O)NCC9=CC=C(C%10=C(C)N=CS%10)C=C9

Molecular Formula

C56H66N10O5S

Molecular Weight

991.25

References & Citations

[1]Nan J, et al. Smarca degraders and uses thereof, US20230072658A1, 2023-03-09

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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