X-376
X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM) . X-376 is a less potent inhibitor of MET (IC50=0.69 nM) . X-376 displays potent anti-tumor activity[1].
Product Specifications
CAS Number
[1365267-27-1]
UNSPSC
12352005
Hazard Statement
H302
Target
Anaplastic lymphoma kinase (ALK) ; c-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ensartinib.html
Purity
98.10
Solubility
DMSO : ≥ 37 mg/mL
Smiles
O=C(C1=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3
Molecular Formula
C25H25Cl2FN6O3
Molecular Weight
547.41
Precautions
H302
References & Citations
[1]Lovly CM, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinaseinhibitors. Cancer Res. 2011 Jul 15;71 (14) :4920-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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