7-Chlorokynurenic acid

7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM) . 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery[1][2].

Product Specifications

CAS Number

[18000-24-3]

Product Name Alternative

7-CKA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/7-Chlorokynurenic_acid.html

Purity

99.86

Solubility

DMSO : 14.29 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(C1=NC2=CC(Cl)=CC=C2C(O)=C1)O

Molecular Formula

C10H6ClNO3

Molecular Weight

223.61

Precautions

H302, H315, H319, H335

References & Citations

[1]Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85 (17) :6547-50.|[2]Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18 (10) :1184-1196.|[3]Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118 (1) :29-32.