Trihexyphenidyl (hydrochloride)

Trihexyphenidyl hydrochloride is a potent and selective M1 muscarinic receptor antagonist. Trihexyphenidyl hydrochloride shows anticholinergic activity, and can be used for Parkinson syndrome or dystonia research[1][2][3].

Product Specifications

CAS Number

[52-49-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Cholinesterase (ChE) ; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Trihexyphenidyl-hydrochloride.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 10 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCCC3.[H]Cl

Molecular Formula

C20H32ClNO

Molecular Weight

337.93

Precautions

H302

References & Citations

[1]Giachetti A, et al. Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine. Br J Pharmacol. 1986 Sep;89 (1) :83-90. |[2]Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs. liposomes. Biomaterials. 2000 Sep;21 (18) :1879-85.|[3]Jilani TN, et al. Trihexyphenidyl. 2022 Feb 27. In: StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing; 2022 Jan–.