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Pterosin B (Standard)

Pterosin B (Standard) is the analytical standard of Pterosin B. This product is intended for research and analytical applications. Pterosin B is an indanone. Pterosin B can be obtained from Pteridium aquilinum. Pterosin B is a Sik3 signaling inhibitor. Pterosin B inhibits Klf5 expression and reduces β-amyloid deposition. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice. Pterosin B inhibits cardiomyocyte hypertrophy, improves cognitive impairment, and lowers blood glucose. Pterosin B can be used in research on arthritis, Alzheimer's disease, pathological cardiac hypertrophy and diabetes[1][2][3][4][5].

Product Specifications

CAS Number

34175-96-7

UNSPSC

12352005

Target

Amyloid-β; KLF; Reference Standards; Salt-inducible Kinase (SIK)

Type

Reference Standards

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Others

Field of Research

Endocrinology; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pterosin-b-standard.html

Smiles

O=C1[C@H](C)CC2=C1C(C)=C(CCO)C(C)=C2

Molecular Formula

C14H18O2

Molecular Weight

218.29

References & Citations

[1]Hannah R.Dexter, et al. A concise stereoselective synthesis of pterosin B. Tetrahedron Letters, Volume 59, Issue 49, 5 December 2018, Pages 4323-4325.|[2]Yahara Y, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016 Mar 24;7:10959.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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