TRi-1
TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].
Product Specifications
CAS Number
246020-68-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tri-1.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CC=C(OC)N=C1S(=O)(C2=CC=C(Cl)C=C2)=O)[O-]
Molecular Formula
C12H9ClN2O5S
Molecular Weight
328.73
Precautions
H302, H315, H319, H335
References & Citations
[1]Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10 (428) . pii: eaaf7444.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7092914 Inquire
Recombinant Vibrio vulnificus Protoheme IX farnesyltransferase (cyoE), partial
Sign In for Pricing
View Details 
ELI-41631h 96 Tests
Human Syntaxin-binding protein 5,STXBP5 ELISA KIT
Sign In for Pricing
View Details