Sodium zirconium cyclosilicate

Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K+ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD) [1][2].

Product Specifications

CAS Number

[17141-74-1]

Product Name Alternative

OPC-14857 (Standard); DM-14857 (Standard),OPC-14857-d8; DM-14857-d18

UNSPSC

12352005

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sodium-zirconium-cyclosilicate.html

Purity

95.0

Solubility

DMSO : < 1 mg/mL (ultrasonic)

Smiles

O[Si]1(O[Si](O)(O[Si](O)(O)O1)O)O.[Na].[Zr].[Na]

Molecular Formula

H6O9Si3.2Na.Zr

Molecular Weight

371.50

References & Citations

[1]Stavros F, et, al. Characterization of structure and function of ZS-9, a K+ selective ion trap. PLoS One. 2014 Dec 22;9 (12) :e114686.|[2]Ash SR, et, al. A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS-9, is safe and efficient. Kidney Int. 2015 Aug;88 (2) :404-11.