GARP&Latent TGF Beta 1 Complex, Human (HEK293, His-Avi)

GARP is a transmembrane protein that acts as a docking receptor for potential transforming growth factor (LTGF-β) and plays a key role in the production and release of active transforming growth factor β (TGF-β) . The presence of GARP affects immune-mediated diseases such as cancer, allergies, and autoimmunity. GARP&Latent TGF Beta 1 Complex Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing rat-derived GARP&Latent TGF Beta 1 Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. GARP&Latent TGF Beta 1 Complex Protein, Human (HEK293, His-Avi), has molecular weight of 70-80 kDa (GARP) & 42-48 kDa & 13 kDa (L, respectively.

Product Specifications

Product Name Alternative

GARP&Latent TGF Beta 1 Complex Protein, Human (HEK293, His-Avi), Rat, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/garp-latent-tgf-beta-1-complex-protein-human-hek293-his-avi.html

Molecular Formula

293135&59086 (Gene_ID) D3ZVD5 (I18-N628) &P17246 (L30-R278) (Accession)

Molecular Weight

Approximately 70-80 kDa (GARP) & 42-48 kDa & 13 kDa (Latent TGF beta 1), based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]Zimmer N, et al. GARP as a Therapeutic Target for the Modulation of Regulatory T Cells in Cancer and Autoimmunity. Front Immunol. 2022 Jul 8;13:928450.|[2]Tran DQ, et al. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A. 2009 Aug 11;106 (32) :13445-50.