Poly (hexamethylenebiguanide) (hydrochloride)

Poly (hexamethylenebiguanide) hydrochloride (PHMB) is an antimicrobial and antiviral agent. Poly (hexamethylenebiguanide) hydrochloride is active against both Gram-positive and Gram-negative bacteria. Poly (hexamethylenebiguanide) hydrochloride works by adsorbing to the surface of cellulose, which can damage microbial cell membranes and interfere with metabolism. Poly (hexamethylenebiguanide) hydrochloride is widely used in medical, clothing and household textiles, and cosmetic fields[1][2][3].

Product Specifications

CAS Number

[32289-58-0]

Product Name Alternative

PHMB

UNSPSC

12352211

Hazard Statement

H302, H317, H318, H330, H351, H372, H410

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/poly-hexamethylenebiguanide-hydrochloride.html

Purity

98.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N=C(NC(NCCCCCCC)=N)NC.[x].Cl.[n]

Molecular Formula

(C8H17N5) n.xHCl

Precautions

H302, H317, H318, H330, H351, H372, H410

References & Citations

[2]Souza C, et al. Mucoadhesive system formed by liquid crystals for buccal administration of poly (hexamethylene biguanide) hydrochloride. J Pharm Sci. 2014 Dec;103 (12) :3914-3923.|[3]Wang W, et al. Study on the Development of Antiviral Spandex Fabric Coated with Poly (hexamethylene biguanide) Hydrochloride (PHMB) . Polymers (Basel) . 2021 Jun 28;13 (13) :2122.|[1]Richard S Blackburn, et al. Sorption of poly (hexamethylenebiguanide) on cellulose: mechanism of binding and molecular recognition. Langmuir. 2006 Jun 20;22 (13) :5636-44.