ASK1-IN-1
ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM) [1].
Product Specifications
CAS Number
[2411382-24-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ASK1; MAP3K; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ask1-in-1-1.html
Purity
99.80
Solubility
DMF : 4 mg/mL (ultrasonic) |DMSO : < 1 mg/mL|Ethanol : < 1 mg/mL (ultrasonic)
Smiles
COC1=NN(C2=NC=CN=C2)C=C1C(NC3=NC(C4=NN=CN4C(C)C)=CC=C3)=O
Molecular Formula
C19H19N9O2
Molecular Weight
405.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Xin Z, et al. Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors. ACS Med Chem Lett. 2020;11 (4) :485-490. Published 2020 Feb 12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP3K5/ASK1
Available Sizes
Curated Selection
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