(RS) -AMPA

(RS) -AMPA ((±) -AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS) -AMPA does not interfere with binding sites for kainic acid or NMDA receptors[1][2].

Product Specifications

CAS Number

[77521-29-0]

Product Name Alternative

(±) -AMPA

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rs-ampa.html

Purity

99.82

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C1C(CC(N)C(O)=O)=C(C)ON1

Molecular Formula

C7H10N2O4

Molecular Weight

186.17

Precautions

H302+H312+H332, H315, H319, H335

References & Citations

[1]Hösli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36 (1) :59-62.|[2]Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249 (4976) :1580-5.