PD 173955 analog 1

PD 173955 analog 1 (Compound 26) is an analog of PD 173955 (HY-10395) . PD 173955 analog 1 is an inhibitor for EGFR kinase, which exhibits antitumor and toxicological properties. PD 173955 analog 1 exhibits an in silico IC50 of 0.19 μM[1].

Product Specifications

CAS Number

[185039-99-0]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-173955-analog-1.html

Smiles

O=C(O)C1=CC=CC(NC2=NC=C(C=C(C3=C(Cl)C=CC=C3Cl)C(N4C)=O)C4=N2)=C1

Molecular Formula

C21H14Cl2N4O3

Molecular Weight

441.27

References & Citations

[1]Bagchi M C, et al., In silico evaluation of 6- (2, 6-dichlorophenyl) -pyrido [2, 3-d] pyrimidin-7 (8 H) -one compounds: an insight into design of less toxic anticancer drugs[J]. Medicinal Chemistry Research, 2016, 25: 123-134.