PD 173955 analog 1
PD 173955 analog 1 (Compound 26) is an analog of PD 173955 (HY-10395) . PD 173955 analog 1 is an inhibitor for EGFR kinase, which exhibits antitumor and toxicological properties. PD 173955 analog 1 exhibits an in silico IC50 of 0.19 μM[1].
Product Specifications
CAS Number
[185039-99-0]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-173955-analog-1.html
Smiles
O=C(O)C1=CC=CC(NC2=NC=C(C=C(C3=C(Cl)C=CC=C3Cl)C(N4C)=O)C4=N2)=C1
Molecular Formula
C21H14Cl2N4O3
Molecular Weight
441.27
References & Citations
[1]Bagchi M C, et al., In silico evaluation of 6- (2, 6-dichlorophenyl) -pyrido [2, 3-d] pyrimidin-7 (8 H) -one compounds: an insight into design of less toxic anticancer drugs[J]. Medicinal Chemistry Research, 2016, 25: 123-134.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Curated Selection
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