L-threo Lysosphingomyelin (d18:1)

L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid. L-threo Lysosphingomyelin (d18:1) is a potent S1P receptor agonist with EC50s of 19.3, 131.8, and 313.3 nM for hS1P1, hS1P3, and hS1P2, respectively[1].

Product Specifications

CAS Number

[105615-55-2]

Product Name Alternative

L-threo-Sphingosylphosphorylcholine

UNSPSC

12352211

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-threo-lysosphingomyelin-d18-1.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=P(OCC[N+](C)(C)C)(OC[C@H](N)[C@@H](O)/C=C/CCCCCCCCCCCCC)[O-]

Molecular Formula

C23H49N2O5P

Molecular Weight

464.62

References & Citations

[1]Im DS, et al. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8) : structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 2001;40 (46) :14053-14060.