L-threo Lysosphingomyelin (d18:1)
L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid. L-threo Lysosphingomyelin (d18:1) is a potent S1P receptor agonist with EC50s of 19.3, 131.8, and 313.3 nM for hS1P1, hS1P3, and hS1P2, respectively[1].
Product Specifications
CAS Number
105615-55-2
Product Name Alternative
L-threo-Sphingosylphosphorylcholine
UNSPSC
12352211
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-threo-lysosphingomyelin-d18-1.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=P(OCC[N+](C)(C)C)(OC[C@H](N)[C@@H](O)/C=C/CCCCCCCCCCCCC)[O-]
Molecular Formula
C23H49N2O5P
Molecular Weight
464.62
References & Citations
[1]Im DS, et al. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8) : structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 2001;40 (46) :14053-14060.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
S1PR1; S1PR2; S1PR3
Available Sizes
Frequently Asked Questions
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